Next came Mujhe Kucch Kehna Hai (2001) opposite Tusshar Kapoor. The film became one of the highest earners of the year. Kareena was lauded for her performance. The same year brought with it Santosh Sivan's epic Asoka, opposite Shah Rukh Khan. Her performance received mixed reactions from critics but Kareena received her first nomination for Best Actress at the Filmfare Awards.
The crowning moment of 2001 for her was the release of Karan Johar's Kabhi Khushi Kabhie Gham which was a huge commercial success. Kareena's performance as "Poo" was well-received by critics and fetched her Filmfare Best Supporting Actress nomination.